How To Deal with Vile Enemies in Borderlands 4

By Ambar Jimenez | 2025-09-23 08:16:54
In Borderlands 4, Vile enemies present a unique and formidable challenge that will test the strategic prowess of any Vault Hunter. You will first encounter these enemies during the "His Vile Sanctum" mission, and understanding their mechanics is key to defeating them. While they are tough, Vile enemies also drop valuable loot and offer a great source of experience, making them a worthwhile foe to engage with.This guide will provide a detailed breakdown of how to approach Vile enemies and what you need to do to take them down efficiently.

Understanding and Countering Vile Enemy Mechanics

To defeat a Vile enemy, you must first understand its unique defenses and attack patterns. Their most defining feature is the Vile Shield, a glowing purple barrier that makes them completely immune to all incoming damage. This shield is not a standard energy shield that you can simply blast through; it has a unique weakness that you must exploit.Your primary objective is to break this shield, which can only be done by shooting the glowing purple crystals on the enemy's body. These crystals are the key to making them vulnerable. You must target and destroy these crystalline growths to temporarily disable the Vile Shield.However, the fight doesn't end there. Vile enemies also have another trick up their sleeve: Vile Ordonite orbs. These orbs can attach to the enemy and provide them with a shield regeneration boost. If you want to maintain your advantage, you must prioritize destroying these orbs as soon as they appear. If you let them reattach to the Vile enemy, you will have to restart the process of breaking their shield.Here’s the step-by-step strategy for defeating Vile enemies:
  • Break the Shield: Focus all your fire on the glowing purple crystals on the enemy's body. These are their weak points and the only way to disable their immunity. Once all the crystals are gone, the Vile Shield will drop, and theenemy will become vulnerable to damage.
  • Destroy Vile Ordonite Orbs: After you've broken the shield, be on the lookout for Vile Ordoniteorbs that spawn around the enemy. These orbs will attempt to re-attachand regenerate the shield. Take them out quickly before they reach their target.
  • Use High-Damage Weapons: Once the shield is down and the orbs are destroyed, you have a limitedwindow to deal significant damage to the enemy. Weapons with highsingle-shot damage, like sniper rifles, are excellent for this. Grenademods or weapons with splash damage can also be highly effective as theycan hit multiple crystals at once, making it easier to break the shield.
  • Manage Shield Regeneration: Be prepared for the shield to occasionally regenerate, requiring you to repeat the initial steps of breaking the crystals and destroying theorbs. The fight becomes a cycle of managing their defenses and thendealing bursts of damage.

While Vile enemies can be challenging, their mechanics are consistent. Byfocusing on breaking their shield and managing the Ordonite orbs, youcan turn a seemingly overwhelming fight into a manageable one.

Platform(s): PlayStation 5 PS5, Microsoft Windows PC, Nintendo Switch 2, Xbox Series X/S
Genre(s): First-person shooter, action role-playing
Developer(s): Gearbox Software
Publisher(s): 2K
Engine: Unreal Engine 5
Release date: September 12, 2025
Mode: Single-player, multiplayer
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