How to Solve Serum Puzzle in Ashes of the Damned in BO7 Zombies

By Ambar Jimenez | 2025-11-17 23:46:20
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Unlock the secrets of Black Ops 7 Zombies with our definitive guide to conquering the Serum Puzzle in Ashes of the Damned. This complex quest is your gateway to completing the main easter egg and securing the powerful DG-2 upgrade for Ol' Tessie. We break down the entire process, from locating every elusive Serum part to solving the final cipher challenge in Yuri's Lab.

Your Blueprint for Serum Part Collection

Before tackling the puzzle, you must gather six unique components scattered across the map. Here is your essential checklist.1. Powder of the Forgotten
  • Prerequisites: Necrofluid Gauntlet (Wonder Weapon) and the Wisp Tea perk.
  • Acquisition: Use your Wisp Tea ability to shatter the hidden mirror inside the Tailor Shop in Ashwood. Return with the Necrofluid Gauntlet and shoot the broken mirror to claim the powder.
2. Widow's Lantern
  • Location Start: Retrieve the Jar of Spores from the kitchen cabinet in the Blackwater Lake cabin.
  • Growth Process: Take the jar to the mushroom-infested dead horse outside Vandorn Farm. After interacting, survive three full rounds to harvest the fully-grown Widow's Lantern.
3. Mysterious Limb
  • Source: This part is a rare drop from Zursa, the zombie bear elite that spawns from Round 16.
  • Key Tip: You must deliver the final blow to Zursa using the Abomination Head's Beam Attack from an upgraded Ol' Tessie to force the item drop.
4. Ravager Eyes
  • Method: Lure a Ravager enemy to an active Saw Blade trap (found at locations like Vandorn Farm Barn).
  • Execution: Let the trap eliminate the Ravager to make the Ravager Eyes available for pickup.

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5. Hoard Husk Chunks

  • Requirement: You must have the Abomination Head upgrade for Ol' Tessie.
  • Process: Patrol the roads between areas and use the vehicle's beam attack todestroy randomly spawning purple-glowing plants. Collect the chunks they leave behind.

6. Human Bones

  • Location: Inside the Vandorn Farm Barn.
  • Steps: Use a Combat Axe to sever the right foot of the hanging corpse. Then,throw a Molotov at the severed foot on the ground. Once the flames diedown, collect the Human Bones.

Solving the Final Serum Puzzle in Yuri's Lab

Once all six parts are secured, head to Yuri's Lab within the ZaryaCosmodrome. The parts will be displayed in bowls, and interacting withthe Powder of the Forgotten will activate the puzzle, displaying threelines of symbols on a chalkboard.

Your goal is to interact with the correct bowls in the exact sequence shown: top symbol first, then middle, then bottom. Use this translation key to identify the correct bowls:

  • > Symbol: Human Bones (1st Bowl)
  • L Symbol: Hoard Husk Chunks (2nd Bowl)
  • C Symbol: Widow's Lantern (3rd Bowl)
  • C. Symbol: Ravager Eyes (4th Bowl)
  • L. Symbol: Mysterious Limb (6th Bowl)

Surviving the Lockdown and Claiming Your Reward

After entering the correct sequence, the vials will emit a red smoke.Interact with the central vial to contribute your blood, initiating alockdown sequence. Crucial Warning: Your health will not regenerate naturally during this fight.

To survive, use the Necrofluid Gauntlet's primary fire and immediatelyreload to siphon health from defeated zombies. Eliminate all waves tocomplete the Serum Puzzle and cement your victory in the Ashes of theDamned easter egg.

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Tags: CoD,BO7, call of Duty,
Platform(s): Xbox One, PlayStation 4 PS4, PlayStation 5 PS5, Microsoft Windows PC, Xbox Series X/S
Genre(s): first-person shooter
Developer(s): Treyarch, Raven Software
Publisher(s): Activision
Engine: IW engine
Mode: Single-player, multiplayer
Age rating (PEGI): +18
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